1)

Find the suitable method from the following to prepare primary amines without the loss of carbons


A) Gabriel method

B) Alkylation method

C) Hoffman Bromamide method

D) Stephen method

Answer:

Option A

Explanation:

Gabriel method is a suitable method for the preparation of primary amines without the loss of carbons. This reaction is used for the preparation of $1^{0}$  aliphatic amine and $1^{0}$ aromatic amine (containing electron-withdrawing group at o-and p-position e.g,$NO_{2}$ group)

Phthalimide on treatment with ethanolic KOH forms potassium salt of phthalimide which on heating with RX followed by either alkaline hydrolysis or hydrazinolysis with hydrazine ($H_{2}N. NH_{2})$  produces the corresponding $1^{0}$ amine.

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